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Diet plays crucial role in Alzheimer’s risk, new study finds

July 26, 2024 5:06 PM IST

Journal of Alzheimer's Disease | Mediterranean diet | Western diet | Ultra-processed foods | Harvard University

A groundbreaking study published in the Journal of Alzheimer’s Disease has revealed the significant impact of diet on the risk of developing Alzheimer’s disease. Researchers have identified specific dietary patterns that can either increase or decrease the likelihood of this devastating neurodegenerative condition.

The study found that plant-based diets, including the Mediterranean diet and traditional cuisines from China, Japan, and India, can reduce the risk of Alzheimer’s. In contrast, the Western diet, characterized by high consumption of saturated fats, red and processed meats, and ultra-processed foods, has been linked to an increased risk.

According to the research, red meat and processed meats like hot dogs significantly raise dementia risk. Ultra-processed foods high in sugar and refined grains also contribute to higher risk. On the other hand, protective foods include green leafy vegetables, colorful fruits and vegetables, legumes, nuts, omega-3 fatty acids, and whole grains.

The study delves into the mechanisms behind these dietary impacts. Meat consumption, for instance, increases risk factors such as inflammation, insulin resistance, and oxidative stress. Ultra-processed foods often lack the anti-inflammatory components and antioxidants found in whole plant foods that help prevent dementia.

Socioeconomic factors also play a role, with poverty driving higher consumption of cheaper, less nutritious foods that promote obesity – a known risk factor for Alzheimer’s.

Alarmingly, the research projects a 50% increase in Alzheimer’s rates in the US by 2038, based on current obesity trends. This estimate closely aligns with projections from the Alzheimer’s Association.

Edward Giovannucci, MD, ScD, Professor of Nutrition and Epidemiology at Harvard University, praised the study, noting that it “makes a strong case” for the link between diet, lifestyle factors, and Alzheimer’s risk.

While further research is needed to fully understand the mechanisms at play, this study emphasizes the potential for individuals to lower their Alzheimer’s risk through dietary choices. However, those who continue to adhere to the Western diet may face a higher risk of developing the disease.

“Grant and Blake provide a comprehensive review on the dietary and other factors that affect the risk of Alzheimer’s disease (AD). Apart from the particular type of diet they demonstrate that the consumption of red meat, insulin resistance, obesity, reactive oxygen species, and oxidative stress, phytochemicals and homocysteine amongst other factors interact with neuroinflammation and play a major role in the aetiology of AD. This treatise provides an excellent overview of modifiable risk factors for AD.”

(Inputs from ANI)

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